2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101704
    Y1 receptor antagonist 1 221697-09-2 99.69%
    Y1 receptor antagonist 1 (H 409-22 isomer) (Example 4) is a neuropeptide Y1 receptor antagonist. Y1 receptor antagonist 1 can be used for the study of cardiovascular diseases, such as vasoconstriction.
    Y1 receptor antagonist 1
  • HY-101708
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea 97627-24-2 99.73%
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
  • HY-101709
    Ricasetron 117086-68-7 98.62%
    Ricasetron (BRL-46470) is a selective and orally active 5-HT3 receptor antagonist. Ricasetron displays little or no affinity for a variety of other neurotransmitter receptors. Ricasetron has anxiolytic and antiemetic effects.
    Ricasetron
  • HY-101755
    Tedatioxetine hydrobromide 960151-65-9 99.83%
    Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. ,
    Tedatioxetine hydrobromide
  • HY-101797
    Veralipride 66644-81-3 99.57%
    Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.
    Veralipride
  • HY-101815
    Lidanserin 73725-85-6 ≥98.0%
    Lidanserin (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist.
    Lidanserin
  • HY-101889
    Cresyl Violet perchlorate 41830-80-2 98%
    Cresyl Violet perchlorate is a red fluorescent stain, which can be used to stain neurons.
    Cresyl Violet perchlorate
  • HY-102086
    MSX3 261717-23-1 98%
    MSX3 is a potent antagonist of adenosine A2A that can reverse the effects of the dopamine antagonist Haloperidol (HY-14538) on effort-related decision making in a T-maze cost/benefit procedure.
    MSX3
  • HY-102091
    (2R,4R)-APDC 169209-63-6 98%
    (2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases.
    (2R,4R)-APDC
  • HY-103066
    Br-PBTC 1839519-57-1 98.0%
    Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2, α2β4, α4β2, α4β4, (α4β2)2α4 and (α4β2)2β2 EC50 ranges from 0.1-0.6 μM. Br-PBTC acts from the c-tail of an α subunit.
    Br-PBTC
  • HY-103090
    NPS ALX Compound 4a 299433-10-6 ≥99.0%
    NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.
    NPS ALX Compound 4a
  • HY-103104
    Fananserin 127625-29-0 99.97%
    Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.
    Fananserin
  • HY-103110
    ST1936 1210-81-7 98.66%
    ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor.
    ST1936
  • HY-103112
    SB 243213 hydrochloride 200940-23-4 98.84%
    SB 243213 hydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.
    SB 243213 hydrochloride
  • HY-103130
    EMD386088 1171123-46-8 99.06%
    EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia.
    EMD386088
  • HY-103140
    Ro60-0175 fumarate 169675-09-6 99.47%
    Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor.
    Ro60-0175 fumarate
  • HY-103145
    PNU-22394 hydrochloride 15923-42-9 98.79%
    PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively.
    PNU-22394 hydrochloride
  • HY-103147
    Mesulergine hydrochloride 72786-12-0 98%
    Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and dopamine (DA) agonist. Mesulergine hydrochloride presentes hyperphagia. Mesulergine hydrochloride has the potential for the research of cognitive processes.
    Mesulergine hydrochloride
  • HY-103154
    SB228357 181629-93-6 99.43%
    SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.
    SB228357
  • HY-103229
    Cl-HIBO 909400-43-7 99.0%
    Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties.
    Cl-HIBO
Cat. No. Product Name / Synonyms Application Reactivity